Journal Articles

40. Yifan Zhang, Xuerui Gong, Zhiyi Yuan, Y.C. Chen, "DNA Self-Switchable Microlaser", ACS Nano. (2020)

Reported by more than 10 medias worldwide:

Nano MagazineNewsBreak,   Phys.Org. Photonics Media...

39.Yunke Zhou, Zhiyi Yuan, Xuerui Gong, Muhammad D Birowosuto,  Cuong Dang,   Y.C. Chen*, Advanced Photonics (2020)

Reported by more than 30 medias worldwide:

Phys. Org. ,  Photonics Media,   Science DailyNewsBreak.... , AAAS

38. Hamim Rivy, Yifan Zhang, Zhiyi Yuan, and Y.C. Chen *, under review (2020)

37. Zhiyi Yuan, Xuerui Gong, and Y.C. Chen *, under review (2020)


36. Y.-C. Chen, et al. "Monitoring Neuron Activities and Interactions via Laser Emissions", ACS Photonics (2020)

35. Zhiyi Yuan, Xuerui Gong, Yunke Zhou, Xiaotain Tan, Cheng Xin, Chaoyang Gong,  and Y.C. Chen*, "Distinguishing Small Molecules in Microcavity with Laser Polarization", ACS Photonics (2020) 

34. Xuerui Gong, Peng Guan, Shilun Feng, Zhen Qiao, Zhiyi Yuan, and Y.C. Chen *,  Advanced Photonics Research (2020) 

The world's first microlaser array printed by office printer.

33. Zhen Qiao, Peng Guan, Xuerui Gong, Zhiyi Yuan, Y.C. Chen* , Advanced Photonics (2020)


32. Daniel Roxby, Hamim Rivy, Chaoyang Gong, Xuerui Gong, G.E. Chang, Y.C. Chen*, "Microalgae Living Sensor for Metal Ion Detection by Nanocavity-enhanced Photoelectrochemistry", Biosensors and Bioelectronics (2020)

31. Ziyihui Wang, Xuerui Gong, Yifan Zhang, Zhiyi Yuan, Y.C. Chen* , "Bio-Electrostatic Sensitive Droplet Lasers for Molecular Detection", Nanoscale Advances (2020)


30. Yifan Zhang, Zhiyi Yuan, Peng Guan, G.E. Chang, Y.C. Chen* , "Tunable Microlasers Modulated by Intracavity Spherical Confinement with Chiral Liquid Crystal", Advanced Optical Materials (2020)


29. Daniel Roxby, Zhiyi Yuan, S. San, G.E. Chang, W.C. Tu, Raymond Lau, Y.C. Chen* , "Enhanced Biophotocurrent Generation in Living Photosynthetic Optical Resonator", Advanced Science (2020) 

Selected as Journal Cover 

27. Zhiyi Yuan, Xiaotain Tan, Xuerui Gong, Shilun Feng, Cheng Xin, Qiushu Chen,  Chaoyang Gong,  and Y.C. Chen* ,  Nanoscale (2020) 

26. Zhiyi Yuan, Peng Guan, Ziyihui Wang, Y.C. Chen* , "Lasing-Encoded Microsensor Driven by Interfacial Cavity Resonant Energy Transfer".  Adv. Opt. Mater.

 10.1002/adom.201901596  (2020)

Collections of Hot Topic: Surfaces and Interfaces

Selected as Journal Cover

25. Y. C. Chen* and Xudong Fan*, "Biological Lasers for Biomedical Applications", Adv. Opt. Mater., 1900377 (2019)

24. Y.-C. Chen*, et al. Laser Recording of Sub-cellular Neuron Activities, BioRxiv (2019)

23. X. Li, Y. Chin, X. Tan, Y.-C. Chen, Q. Chen, and X. Fan*, “Ultrasound Modulated Droplet Lasers”. ACS Photonics, 6, 531–537 (2019) 

22. X. Tan, Q, Chen, Y.-C. Chen, and X. Fan*, “     A Fast and Reproducible ELISA Laser Platform for Ultrasensitive Protein Quantification”,   ACS Sensors 

DOI: 10.1021/acssensors.9b01795   (2019)

21. X. Wu, Y. Wang, Q. Chen, Y.-C. Chen, and X. Fan*, “High-Q, low-mode-volume microsphere-integrated Fabry-Pérot cavity for optofluidic lasing applications”.  Photonics Research 7, 50-60 (2019)

Top 10 downloaded articles published in the first quarter of 2019


20. Y.-C. Chen, A. Nadeem, Q. Chen, and X. Fan*, “Chromatin Laser Imaging Reveals Metabolic Studies in Colon Tissue”. Biomedical Optics Express 10, 838-854 (2019)




Before Joining NTU Singapore in 2018. 9 ---------------------

19. X. Tan, D. Anu, J. Day, H. Tan, Y.-C. Chen, A. Shikanov, and X. Fan*, “Rapid Mouse FSH Quantification and Estrus Cycle Analysis Using an Automated Microfluidic Chemiluminescent ELISA System”. ACS Sensors (2018)


18.  X. Wu, Q. Chen, Y.-C. Chen, B. Wu, R. Coleman, L. Tong, and X. Fan*, “Nanowire lasers as intracellular probes”, Nanoscale, (2018)

17. Y.-C. Chen, X. Tan, Q. Chen, R. Coleman, and X. Fan*, “A Robust Tissue Lasing System for Cancer Diagnosis and DNA Analysis of FFPE Tumor Biopsy”. Lab. Chip, 18(3)  (2018)


16.  Y.-C. Chen, X. Tan, Q. Sun, Q. Chen, and X. Fan*, “Laser-emission imaging for high contrast cancer screening and immuno-diagnosis”. Nature Biomed. Eng. 1(9) (2017)  IF=17.1  Top 0.2%


Featured as “Behind the paper” in Nature BME.

Reported by Nature 

Reported by Nature Methods

Reported by Electro Optics 

15.  Q. Chen, Y.-C. Chen, Z. Zhang, B. Wu, R. Colman, and X. Fan*, “An Integrated Microwell Array Platform for Cell Lasing Analysis”, Lab. Chip (2017) IF: 6.1 n/m=7%


14.  Y.-C. Chen, Q. Chen, W. Wang, T. Zhang, and X. Fan*, “Versatile Tissue Lasers based on High-Q Microcavities”, Lab Chip, 17, 538-548 (2017)  IF: 6.1 n/m=7%


13.  Y.-C. Chen, Q. Chen, X. Fan*, “Lasing in Blood”, Optica, 3(8) 809-815. (2016)  IF: 9.2; N/M= 3%

Featured as Journal Cover.

Top downloads of the year.  

More than 30 media coverages worldwide:


“The New Scientists”, “RSC-Chemistry World”,

“Daily Mail”, “BioOptics World”, “Phys. Org.”,

“Science-Alert”,“Michigan Engineering”, “Mirrors”,

“Singapore News”, “Francais-Express”,

“Digital Trends”, “YAHOO News!”, “MedGadget”,

“Truebreaking-news”, “i-Tech Post”, “Engadget”,

“Futurism”, “Big Ten Network”, etc.


12.  Y.-C. Chen, Q. Chen, X. Fan*, “Optofluidic Chlorophyll Lasers”, Lab Chip, 16, 2228-2235. (2016) IF: 6.9


Selected as HOT Article

Reported by LOC Blogs



11.  K.-S. Brink*+, Y.-C. Chen+, Y. Wu, D.-B. Shieh, R.-R. Reisz, C.-K. Sun, “Dietary Adaptions in the Ultrastructure of Dinosaur Dentine via Harmonic Generation Microscopy”, J. R. Soc. Interface  13-25 (2016) 


Featured as Journal Cover Story by Royal Society of Chemistry


10.  Y.-C. Chen, Y. Wu, K. Brink, D.-B. Shieh, R.-R. Reisz, C.-K. Sun*, “Third Harmonic Generation Microscopy Reveals Dental Anatomy in Ancient Fossils”, Opt. Lett. 40(7): 1354-1357 (2015)

       Highlighted by Optics & Photonics News


9.  Y.-C. Chen, H.-C. Hsu, Y.-H. Cheng, C.-K. Sun*, “Third Harmonic Generation Susceptibility Spectroscopy in Free Fatty Acids”, J. Biomed. Opt., 9:095013 (2015)


8. M.-Y. Lin, T.-H. Tsai, Y.-L. Kang, Y.-C. Chen, Y.-H. Huang, L.-A. Wang, and S.-C. Lee, “Design and Fabrication of Birefringent Nano-grating Structure for Circularly Polarized Light Emission”, Opt. Express, 2 (7).  (2014)


7. M.-Y. Lin, Y.-L. Kang, Y.-C. Chen, L.-A. Wang, C.-C. Wu and S.-C. Lee, “Plasmonic ITO-Free Polymer Solar Cell”, Opt. Express, 52(S2).   (2014)


6. Y.-C. Chen*, Y.-T. Chang, H.H. Chen, F.-T. Chuang and S.-C. Lee, "Enhanced Transmission of Higher Order Plasmon Modes with Random Au Nanoparticles in Periodic Hole Arrays," IEEE Photon. Technol. Lett., Vol.25 No.1,  (2013)


5. Y.-T. Chang*, Y.-C. Chen, M.-R. Tang, W.-C. Chi, M.-H. Tsai, “Emission Enhancement in Tri-Layer Ag/SiO2/Ag Plasmonic Thermal Emitter by Using Hexagonal Dimple Array as Top Layer”, IEEE Photon. Technol. Lett., 25 (14), (2013)


4. C.-H. Cheng, Y.-C. Chen, H.-H. Chen and S.-C. Lee*, “Improved Performance of Plasmonic Thermal Emitter via Incorporation of Gold Nanoparticles”, IEEE Photon. Technol. Lett., 25(17).  (2013)


3. Y.-C. Chen*, H.-H. Hsiao, C.-T. Lu, H.-H. Chen, H.-C. Chang and S.-C. Lee, "Effect of Paired Apertures in a Periodic Hole Array on Higher Order Plasmon Modes’’, IEEE Photon. Technol. Lett., Vol.24 No.22. (2012) 


2. C.-T. Huang, Y.-C. Chen and S.-C. Lee*, “Improved photoresponse of InAs/GaAs quantum dot infrared photodetectors by using GaAs1-xSbx strain reducing layer”, Appl. Phys. Lett., 100 (4) (2012)


          APL Top Frontier News 

          Editor’s Top Picks of in 2012


1. F.-T. Chuang, P.-Y. Chen, Y.-W. Jiang, M. Farhat, H.-H. Chen, Y.-C. Chen and Si-Chen Lee*, ‘‘Nanoprojection Lithography Using Self-Assembled Interference Modules for Manufacturing Plasmonic Gratings’’, IEEE Photon. Technol. Lett., (2012)





Conference Proceedings


Y.-C. Chen, “Laser Emission Microscopy: A Novel Tool for High-contrast Cancer Screening with Nuclear Biomarkers ”, CLEO ‘18, San Jose, USA, 2018 (Invited Talk)


Y.-C. Chen *, “Applications of Bio-lasers in Cellular and Tissue Analysis”, Gordon Research Conference ’18, New Hemisphere, USA, 2018  (Invited Talk)



Y.-C. Chen, Q. Chen, X. Fan*, “Optofluidic cell and tissue lasers and their novel biomedical applications”, SPIE Photonics West ’18, San Francisco, USA, 2018  (Invited Talk)



Y.-C. Chen*, “Optofluidic Tissue Lasers: Potential Applications in Biomedicine”, International Conference on Optofluidics ’17, Singapore, 2017  (Invited Talk)



Y.-C. Chen, Q. Chen, X. Fan*, “Multiplexed Subcellular Lasing in Cancerous Tissue for Molecular Diagnostics”, CLEO ‘17, San Jose, USA, 2017  (Oral, Special symposium)



Y.-C. Chen, Q. Chen, X. Fan*, “Neuron Lasers: Calcium Imaging of Spontaneous Neuronal Activities”, CLEO ‘17, San Jose, USA, 2017 (Oral)   “Highly competitive Postdeadline accepted paper, < 10 % acceptance”



Y.-C. Chen, Q. Chen, W. Wang, T. Zhang, X. Fan*, “Multiplexed Lasing in Tissues”, SPIE Photonics West ‘17, San Francisco, USA, 2017  (Oral Presentation)



Y.-C. Chen, Q. Chen, X. Fan*, “Biologically Inspired Optofluidic Lasers via Chlorophylls”, CLEO ‘16, San Jose, USA, 2016  (Oral)


Y.-C. Chen, Q. Chen, X. Fan*, “Optofluidic Lasers in Blood”, CLEO ‘16, San Jose, USA, 2016 (Oral Presentation)

“Highly competitive Postdeadline accepted paper, < 10 % acceptance”


H.-C. Gao, Y.-C. Chen, C.-M. Lee, and C.-K. Sun, “Visualize susceptibility information with third harmonic generation microscopy and spectroscopy,” Focus on Microscopy (FOM 2016), Taipei, Taiwan (2016).


Y.-C. Chen*, C.-K. Sun, Y. Wu, D.-B. Shieh and R.R. Reisz, “3D Visualization of Dental Anatomy in Ancient Fossil by Using Third Harmonic Generation Microscopy”, CLEO ‘14, San Jose, USA, 2014  (Oral Presentation)

Chosen as Topical Highlight by OSA


S.-Y. Lee*, Y.-H. Lai, K.-C. Huang, Y.-C. Chen, C.-K. Sun , “Realization of Multiphoton Photoacoustic Microscopy via a Loss Modulation Technique”, CLEO ‘14, San Jose, USA, 2014


Y.-C. Chen*, H.-H. Hsiao, C.-T. Lu, H.-H. Chen, H.-C. Chang and S.-C. Lee, “Enhancing the transmission of higher order plasmon modes through periodic hole array with paired apertures as the basis”, The 3rd International Conference on Metamaterials, Photonic Crystals and Plasmonics, (META’12) Paris, Apr. 2012 (Oral Presentation)


Y.-C. Chen*, C.-K. Sun, Y. Wu, D.-B. Shieh, T.-D. Huang and R.-R. Reisz, “Harmonic Generation Microscopic Imaging Studies for Ancient Dinosaur Fossils”, International Conference on Optics and Photonics in Taiwan, Taoyuan City, Taiwan, Dec. 2013 (Oral Presentation)


Y.-C. Chen*, H.-C. Hsu, Y.-H. Cheng, C.-K. Sun*, “Third Order Susceptibility Studies of Resonance Enhancement in Free Fatty Acids by Vibrational Second Overtones and Combinational Bands of CH2 Group”, International Conference on Biomedical Molecular Imaging, Taipei , Nov. 2014


C.-H Cheng, Y.-C. Chen, H.H Chen, S.C Lee, “Enhanced Emission of Plasmonic Thermal Emitter by Incorporating Annealed Gold Nanoparticles via Periodic Hole Arrays”, (META’13) Dubai, May. 2013


Y.-C. Chen and J.-I. Chyi*, “Activation energy studies for type II InAs/GaAs quantum dots solar cells with GaAs1-xSbx as stain-reducing layer”, The 1st Science Symposium for Young Scientists in NCU, Taoyuan, Taiwan,  June, 2010 (Best Outstanding Poster Award)


 C.-T. Huang, Y.-C. Chen and Si-Chen Lee*, “Photoresponse improvement of InAs/GaAs quantum dot infrared photodetectors using GaAs1-xSbx overgrown layer”, The 5th International Conference on Solid State Devices, Japan,   July, 2011